(Though the Wachowskis' "Bound" is fucking dynamite, and involves quite a...uh..."friendship" between its two leads: Jennifer Tilly and Gena Gershon)
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There's an exception for when the girls aren't just friends, but naked friends.

See also: Wild Things.
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also if all but one of them gets gruesomely murdered
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The power of “Two lesbians against the mob” as an elevator pitch is incontrovertible.
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