pretty much everything, it's a completely different setting. but basically the focus is much more personal as there isn't some vast cosmic war, werewolves are the guardians of the border between the spirit world. only five playable tribes, which are ideological/focused on hunting specific threats.
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the spirit world is specifically only the spiritual reflection of the world and doesn't extend into like the High or Low Umbra, which instead are separate metaphysical realms werewolves can't normally access. it's also hostile to PCs because of their role and the prehistoric sin of their tribes.
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