I get the lesson, but why'd you suggest adding dmso in the first place?

Im not through my coffee yet 😅

April 09, 2026 - 15:43 UTC

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Complex natural product extracts...want it all soluble for the nmr. Often complex solubilities, and yeah as our colleague notes...DMSO dissolves almost everything. Especially when you dont know what you have.
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Ah I had assumed you wanted the crystals over the NMR. That's the inorganic chemist in me I guess 😅
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TFA is also excellent. But not a good idea when trying to isolate natural products.
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I don't remember much from my undergrad lectures at this point. But I do remember - (basically) everything dissolves in DMSO.
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In what turned out to be my last week in the wet lab I did a recrystallisation from DMSO. Saw tiny crystals starting to grow and then I went home. Two days later I was in hospital. Never got to see if it was pure. Still bugs me 13 years later
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But if it's crystalizing wouldn't you not want to not solubilize it?
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even (certain) PFAS, which strangely excites me
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